How Long Does It Take for CBD Oil to Work?

It is less likely still not to know the wonders of Cannabidiol or CBD oil and how long does it take for CBD Oil to work. It works miraculously to alleviate chronic pain, anxiety, insomnia, and several other medical conditions. The usage of CBD oil is as simple as swallowing a pill. All you have to do is sit down. Open your favorite CBD oil bottle’s cap and prepare to go on a relaxing journey. Do not worry about the application. It is all available on the internet as well as at the back of the non-intoxicating CBD oil bottle.

Every new CBD oil user has tons of questions. Before the first application, every user might ponder on some questions like:

  • How long will the CBD oil be effective?
  • How long does it take for CBD oil to work?

We need to support all these answers through clinical research, as it is not easy to answer them without clinical proof. But with all the research available and unwavering confidence, we can still guide you through the whole process. Before knowing the answer to your question: ‘How long does it take for CBD oil to work?’, we can study how CBD oil interacts with our body receptors.



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How Does CBD Oil Interact with the Human Body?

Cannabidiol, through various mechanisms, interacts with our brain and body both. However, it is just the beginning of all the research to discover the complicated relationship between our body and CBD. As far as we have come, it is safe to stay that Cannabidiol might relieve specific ailments.

After entering in our body, the Cannabidiol first interacts with our central nervous system. After that, it targets various proteins in our bodies. The critical place of this interaction is present within the endocannabinoid system.

To be more specific, the CBD interacts with two primary receptors CB1 and CB2.  However, CBD is unlike THC. THC usually binds with these two receptors and creates the ‘stoned’ effect. CBD has a non-intoxicating impact.

When we introduce Cannabidiol to our endocannabinoid system, it absorbs anandamide. It is a natural cannabinoid that is responsible for regulating pain.

Other than reacting with CB1 and CB2 receptors, Cannabidiol interacts with other proteins not related to the ECD system. For example, it interacts with vanilloid receptor TRPV1 as well as serotonin receptor 5-HT1A.

We know much about the anti-inflammatory and anxiety relief properties of Cannabidiol. Little did we know that they could also stem from one of these activated biological pathways.

The relationship between CBD and the human body is far complicated than we can imagine. It is straightforward to understand how CBD interacts with our bodies. But, knowing how long does it take for CBD oil to work on our body is still difficult to interpret.

Similar questions like, ‘How long does it take for CBD to lose its effect?’ are based on several factors. One of the factors is the CBD consumption method. Another factor is the quality of the CBD product. A person’s body can also be a factor when it comes to its effectiveness.

The Consumption Method Matters

The consumption method plays a crucial role in determining the effectiveness of Cannabidiol. We extract CBD in various ways and are available in many forms. Each form has its own onset time, efficacy, and effects on the body. You can find more in this article about How to take CBD oil.


Ingestion is one of many ways to consume CBD oil. This method entails administrating few CBD oil drops directly into your mouth. According to CBD oil users, it is the easiest and quickest way to feel the potential benefits of Cannabidiol.

However, you must swallow it after good 2-3 minutes so that it can enter your bloodstream gradually. Consuming it sends it directly to your liver through your digestive tract. Here, the oil is broken down into molecules to get mixed with your bloodstream.

Several research studies indicate that when CBD is broken down by the liver, the process is known as the ‘first-pass effect.’ In this phenomenon, the liver reduces the cannabidiol concentration from the compounds. After that, it sends the remainder to the bloodstream.

Ingesting CBD edible is another way of CBD intake. It works on the same principles. It can be eating CBD gummies or adding a few drops of CBD oil into your food. However, these consumption methods take long ways to reduce CBD concentration before they can finally send the remainder to your bloodstream.

Sublingual Consumption Method

You can also consume CBD oil by administrating a few drops under your tongue. However, you must swallow it after 1-2 minutes. This method enables the mucous membranes that are located in your mouth to absorb CBD oil. It then bypasses the CBD oil to your liver and then to your bloodstream.

As compared to the ingestion method, it allows the CBD oil users to skip the liver metabolization process. Hence, it will enable the CBD oil to reach the bloodstream more quickly.


We consider Inhalation as an effective way to take CBD. You can either inhale it through a vape pen or smoke a CBD strain to alleviate chronic pain symptoms. This method is efficient as the CBD gets absorbed in the body quickly.

When we smoke CBD, we send the cannabinoids directly to our lungs. From here, they go to your bloodstream and circulate throughout your body. You can feel the effects shortly after inhaling as the process hardly takes 3 minutes.


Topical application refers to applying CBD oil directly on to your skin. It then gets absorbed by localized receptors on the surface of your skin. In some cases, we use infused CBD topicals to overcome the high absorption rate of the skin.

When CBD oil is applied directly to the skin, its effect lasts as long as 90 minutes. That is why we use this method, usually for chronic pain relief.

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Your CBD Oil Dosage Matters Too

The way CBD oil interacts with your body or excretes from your body says a lot about your body. The effectiveness and the dosage vary from consumer to consumer.

Let’s discuss several factors that influence the dosage.

Body Weight

The weight that you see on the weighing scale determines the amount of CBD oil you must take to alleviate pain or other symptoms. For example, someone with a higher BMI index would require more CBD oil. Body mass also determines the way CBD interacts with your body cells.

Just like THC, the cannabinoid also gets stored in fat cells. That is why it can remain in your body even after its effects diminishes.


The metabolism rate of your body also affects the way CBD interacts with your body. The body’s metabolic rate usually defines the time it will take for CBD to break down and synthesize. If you have a low metabolic rate, the cannabinoids will metabolize at a lower rate.

Frequency of Use

Your body was just one factor that influenced the effectiveness of CBD oil. The product itself and it is quality also determine the time it will take to work. Once you get a high-quality CBD oil, you need to find the daily dosage regimen for it to start working effectively. Now, you might be wondering again: ‘how long does it take for CBD oil to work?’,’ At which frequency should I use it to see optimal results?’

The answer mainly depends on the product’s quality and the amount they offer. The reputable CBD oil manufacturers give proper instructions on how to use it, especially if you are targeting specific ailments. By experimenting a little bit could help you find the optimal dosage you need.

CBD Dosage

Settling down or sticking to one CBD dosage is very important for the whole treatment. Moreover, it will also influence how long it will stay in your body.

There’s zero need to be worried about the dosage or amount if you are using hemp-derived CBD oil. They do not give you an intoxicated feeling. However, it is still recommended by experts to start with a little dosage and make your way up.

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How Long Does It Take for CBD Oil to Work and Get Out of Your System?

We have already discussed the factors that influence how long it takes for CBD oil to work. How about we discuss some factors affecting how long it takes for CBD oil to get out of your body. Again, the elements are the same, as we have mentioned before. However, we will try to back them up with scientific research and evidence.

A study carried out in 2007 indicated that the effect of CBD remains for 72 hours after smoking. This method seemed appealing for those suffering from pain.

They give to the volunteers in this study a soft gelatin capsules containing 1.5 milligrams of CBD and 2.5 milligrams of THC. Later they notice that CBD was detectable in blood for up to 6 hours.

Most consumers are afraid that consuming CBD would lead them to fail a drug test. But it is wrong as the testers specifically look for traces of THC and its metabolites.

However, there’s still a chance as CBD oil has little to no amount of THC presence. But you can only detect this if you take a large dose, that is 1000-2000 milligrams of CBD.

If you are still worried about the drug screening, look for broad-spectrum CBD products. They contain pure CBD isolate. The refine the Full-spectrum CBD oils to destroy the traces of THC. Products with CBD isolate contain no THC that comes from hemp during the extraction.

If you are a new user and worried about which CBD oil to buy, do a little research on the internet. Always go for CBD oils that have third-party lab testing certificates. Moreover, look out for information listed on the product. Do not mistake CBD oil by hemp oil or hemp seed oil.



Disclaimer: The Federal Food, Drug, and Cosmetics requires this disclaimer. We collected this information from different sources for the benefit of our consumers. The Food and Drug Administration did not evaluate the statements made regarding these products. The effectiveness of these products is not confirmed by FDA-approved research. These products are not meant to cure, diagnose, treat, or prevent any disease. The information presented here is not intended as a substitute for knowledge from health-care practitioners. It is also not meant as an alternative to expertise from health-care practitioners. You should always consult with your doctor and ask about the risk of interactions or complications before using any products.