How to Try CBD Oil for Depression??

Before we get into if we can use CBD Oil for Depression, let us discuss Depression first. Mental sickness and psychological traumas are the topics that people these days debate on, yet they don’t normalize yet. One out of four people face such illness, but more than half of the affected population prefers to suffer in silence due to social dilemmas. Disturbance in one’s mental health can affect physical health, social life, and personal relationships.  The most common mental illness faced by many people is depression.  According to the World Health Organization, about 300 million people worldwide are fighting depression.

Also, it is the leading cause of disability. Being more common in youngsters, especially women, it is a cause leading cause of suicide in that age group.  We can take several steps to prevent suicide and self-harm that is frequent in these patients.

With many support groups created online, help center numbers and suicide protection programs can benefit many people. They introduce medicines that are contributing to the struggle against this disorder. A recently added drug is CBD Oil that a lot of consultants are recommending regarding help with depression.


About CBD

CBD is the abbreviation of Cannabidiol, which people are more familiar with as hemp or Marijuana. It is the principal constituent of the extract from the Cannabis plant. It takes about forty percent of the extract and over one hundred different cannabinoids that we can find in the plant. The name of compounds from cannabis is according to the amount of tetrahydrocannabinol (THC) that mostly it’s been an associate with psychomotor effects.

More than a century ago, they isolated the specimen from the plant for research on its psychoactive effects. Through this research, people find that most of the psychotomimetic for its therapeutic effects.

How Does CBD Work?

CBD is also produced naturally by the human body in a certain amount. It involves a neurotransmitter in the endocannabinoid system. This system is responsible for controlling moods, thirst, appetite, thoughts, emotions, pain perception, etc. CBD acts on two receptors. Type 1 receptors are present throughout the body and most dense in the CNS, thus, explaining the use of CBD in movement disorders, chronic pain relief, and psychological disorders. Type 2 receptors are present on the immune cells and control pain and inflammation.

Uses Of CBD Oil

Ever since they legalize medicinal Marijuana or CBD, people treat many diseases with it. The essential applications include movement disorders such as hyperkinesias, dyskinesia, dystonia. Also, psychological disorders like Alzheimer’s disease, Post Traumatic Stress Disorder (PTSD), Parkinson’s disease, Obsessive-Compulsive Disorder (OCD), anxiety, insomnia, depression, Epilepsy, generalized seizures, and many others.

After the discontinuation of the concept of CBD acting only on type 1 receptors, we treat several chronic conditions that include Inflammatory Bowel Disease (IBD), Crohn disease,  glaucoma. Also, chronic pain related to arthritis, multiple sclerosis, cancer, migraine, osteoporosis, and other bone conditions.

What Triggers Depression?

In terms of psychology, depression is a constant state or mood of being sad and hopeless with loss of self-esteem. Often, we associate depression with loss of appetite, insomnia, and sometimes even anxiety and PTSD. However, in biochemical language, we can define depression as a state of decreased serotonin level. It is one of the oldest mental illnesses, and its history dates back to the times of ancient Greeks Hippocrates, who used to call this Melancholia.

It can be caused by the loss of a loved one, after severe mental trauma, a chronic diseased condition like cancer or tumors, post-partum. Some people get depression with changes in weather like autumn and winter. A condition termed as Seasonal Affective Disorder.


Depression can be confused with sadness or grief. But these two are different in many ways. In pain, the feelings of sadness come in episodes while in depression, the opinions are constant. A depressed person feels worthless and has a state of self-hatred while this is absent in grief. The two conditions also differ on biochemical levels.


The symptoms of depression included changes in sleeping and eating patterns, loss of interest in one’s hobbies, state of constant fatigue, difficulty in concentrating and decision making, slow speech, suicidal thoughts, and feelings of worthlessness. The occurrence of these symptoms for more than two weeks confirms the diagnosis of depression.

cbd oil for depression

Depression And CBD Oil

Fortunately, depression can be treated in many ways, from pharmacological approaches to talk therapies or counseling. An open discussion with a professional or a support group has improved treatment plans. In chronic cases, rehabilitation programs can be beneficial.  Among many other drugs, CBD Oil is now widely used in depression treatment. It works to improve the symptoms of depression rather than curing the disease.


CBD modulates the actions of the neurotransmitter in the endocannabinoid system.  And this causes the release of serotonin, which is responsible for the well-being of a person.


CBD also causes up-regulation of the receptors on which serotonin acts.


Cannabidiol has shown pieces of evidence of causing regeneration of nerve fibers in the hippocampus of the brain. This region is responsible for storing memories and is vulnerable to shrinkage during the state of depression.


BDNF is a protein that the nerve fibers require in order to regenerate them. People obtain enough evidence to support the theory that CBD increases the production of this protein.


We also know as glitazone receptors. CBD binds to PPAR gamma and signals the DNA to produce neuron protectors and anti-inflammatory compounds.

Multiple kinds of research have proved that CBD has its effects on depression as the suicidal rates have dropped among people treated with Cannabidiol. Also, CBD relieves the symptoms of anxiety, making it better for such people who have anxiety associated with depression.

Other approaches in treatment include psychotherapy and psychotropic medications, including tricyclic antidepressants and Selective Serotonin Reuptake Inhibitors, Monoamine Oxidase Inhibitors. All these drugs aim to keep up with the level of serotonin and norepinephrine. In cases of severe depression, they use Electroconvulsive Therapy (ECT), a process of passing an electric current through brain fibers.

CBD Dosages

People can take CBD as oil, capsule, vaping, and smoking of the leaves and topical forms. In the treatment of depression, usually, they use capsules and tinctures. We prefer the dosage in the least minimum amount and increase if required. Mostly, they give a dose of 5 to 1o milligrams daily unless they achieve the needed effects. The impact of such a treatment can last up to 24 hours. However, the results appear after 90 minutes of ingestion. One of the reasons people prefer CBD over other drugs is its fast onset of actions.

Often, people vaporize to treat acute effects and fast symptom relief.  CBD is also available in the form of gel capsules that are available as 25 mg per pill, which is safe. We recommend to consult your physician and act according to the doctor’s prescription. You should not prefer Self-medication since drug effects with more than optimum doses can be hazardous. You should not discontinue the drug abruptly. It would help if you reduced the dosage slowly to avoid rebound symptoms.

Side Effects Of CBD Oil

Although it has a safer profile for its therapeutic index, we can envolve some side effects with CBD. These include decreased CNS outflow that causes dry mouth, low blood pressure, lightheadedness, drowsiness, etc. Other reports include fatigue, bowel disturbances, fatigue, changes in weight, and sometimes even liver injury. Doctors recommend being cautious with patients having an underlying liver disease.

If doses are more than required or stopped abruptly, the side effects of CBD include physical and psychological dependence, addiction, with drawl symptoms, personality changes. That’s why you should reduce the medication slowly.

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Final Verdict

Day by day, the increasing prevalence of psychological disorders has put the pharmacological industries on a strict track. They conduct a lot of Researches, and studies to come up with drugs that can put an end to this struggle.

Although they put many drugs and therapies forward, they still need to produce a drug with the least side effects and a safe usage profile. CBD is the most beneficial of the many medications that we use to treat depression. They are considering its few side effects, fast mechanism of action, and long half-life. Many doctors throughout the world are recommending it.

Even though mental illness is widespread and being normalized by public speakers and celebrities, about 50 percent of the people do not seek professional help. In contrast, others rely on drugs only. But no pharmacological approach can benefit a person unless there is an overall change in lifestyle and thought to process. Thus, they need to treat a patient with drugs and psychotherapies.



Disclaimer: The Federal Food, Drug, and Cosmetics requires this disclaimer. We collected this information from different sources for the benefit of our consumers. The Food and Drug Administration did not evaluate the statements made regarding these products. The effectiveness of these products is not confirmed by FDA-approved research. These products are not meant to cure, diagnose, treat, or prevent any disease. The information presented here is not intended as a substitute for knowledge from health-care practitioners. It is also not meant as an alternative to expertise from health-care practitioners. You should always consult with your doctor and ask about the risk of interactions or complications before using any products.